I argue that we cannot fully understand Aristotle’s position on political stability and state preservation in the Politics with paying close attention to his Eudemian Ethics. We learn from considering the Politics and the Eudemian Ethics in concert that even ‘correct’ regimes are unstable when citizens do not possess full virtue. Aristotle introduces his formal account of the knowledge requirements for virtue in Eudemian Ethics 8.3, and he applies these knowledge requirements as an explanation for state decline in Politics 2.9 (...) when discussing the Spartans. If we primarily focus on the Nicomachean Ethics as Aristotle’s single essential ethical work, we will not learn the lesson he intends his readers to take away from the Spartan discussion in the Politics: that virtue requires correct understanding of the hierarchy and structure of the good life. This knowledge prevents the erosion of the virtues of character and the decline of political regimes. (shrink)

BackgroundSarcomas are a diverse group of neoplasms that vary greatly in clinical presentation and responsiveness to treatment. Given the differences in the sites of involvement, rarity, and treatment modality, a multidisciplinary approach is required. Previous literature suggests patients with sarcoma suffer from poorer quality of life especially physical and functional wellbeing. Adolescent and young adult patients are an underrepresented population in cancer research and have differing factors influencing QoL.MethodsRetrospective analysis of Young Adult patients enrolled in the Sarcoma Tissue Repository at (...) University of Iowa. QoL was assessed using the self-report FACT-G questionnaire at enrollment and 12 months post-diagnosis; overall scores and the 4 wellbeing subscales were calculated. Linear mixed effects models were used to measure the association between the rate of change in FACT-G subscale scores and baseline clinical, comorbidity, and treatment characteristics.Results49 patients were identified. 57.1% of patients had a malignancy involving an extremity. Mean FACT-G scores of overall wellbeing improved from baseline to 12 months. Social and emotional wellbeing did not differ significantly between baseline and 12 months. Physical wellbeing and functional wellbeing scores improved from baseline to 12 months. No difference was seen for FACT-G overall scores for age, sex, laterality, marital status, performance status, having children, clinical stage, limb surgery, chemotherapy, or tumor size. A difference was demonstrated in physical wellbeing scores for patients with baseline limitation compared to those with no baseline limitation. A difference was demonstrated in social wellbeing based on anatomical site.ConclusionYoung adults with sarcoma treated at a tertiary center had improvements in overall reported QoL at 12 months from diagnosis. Overall baseline QoL scores on FACT-G were lower than the general adult population for YA patients with sarcoma but at 12 months became in line with general population norms. The improvements seen merit further investigation to evaluate how these change over the continuum of care. Quality of life changes may be useful outcomes of interest in sarcoma trials. (shrink)

We establish Hjorth's theorem that there is a family of continuum-many pairwise strongly incomparable free actions of free groups, and therefore a family of continuum-many pairwise incomparable treeable equivalence relations.